910463-68-2

Smilepep (Hangzhou) Pharmatech Co.,ltd，located in Hangzhou, Zhejiang Province, is an innovative enterprise specializing in research and development, production, sales of pharmaceutical raw materials and their derivatives. We supply high quality Sermaglutide (CAS 910463-68-2), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is Semaglutide ?

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. Semaglutide injection is used to treat type 2 diabetes.

What is the CAS number for Sermaglutide ?

The CAS number of Sermaglutide is 910463-68-2.

More information of Sermaglutide 910463-68-2 are:

What is Sermaglutide (910463-68-2) used for?

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with a long elimination half-life, allowing subcutaneous (sc) administration once per week. Both the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) have approved once-weekly sc semaglutide for the treatment of type 2 diabetes mellitus (T2DM). The weight loss efficacy of once-weekly sc semaglutide appears to be superior compared with the other once-weekly GLP-1 RAs in patients with T2DM. Semaglutide was recently evaluated as an antiobesity drug in a phase II dose-finding trial, which demonstrated superior weight loss efficacy of once daily sc semaglutide compared with both placebo and once daily 3.0 mg liraglutide in patients with obesity but without T2DM. 

Semaglutide as a promising antiobesity drug

Georgios A. Christou, Niki Katsiki, John Blundell, Gema Fruhbeck, Dimitrios N. Kiortsis

Obesity, Volume20, Issue6 June 2019 Pages 805-815

The magnitude of semaglutide-induced weight loss in this study exceeded the criteria of both the EMA and FDA for antiobesity drugs, and there were no safety concerns, indicating the eligibility of once daily sc semaglutide as a future antiobesity drug.

The discovery and development of liraglutide and semaglutide

LB Knudsen, J Lau

Frontiers in endocrinology, 2019

When designing semaglutide, a realistic concern was if it would be possible to stabilize a GLP-1 analog against systemic clearance to achieve plasma levels sufficient to control blood glucose following OW dosing. Initial findings with liraglutide, using both in vitro and in vivo (animal models) GLP-1R assays, had shown it was challenging to achieve an optimal balance between a long plasma half-life and sufficiently high GLP-1R affinity in the presence of albumin.

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